Monomix Core chromatographic media, designed and developed by Sepax Technologies, Inc., is a novel polymeric chromatographic medium with a core-shell(s) hierarchical layer structure, a narrow size distribution, and desired porous structure, which combines a size exclusion separation and various binding chemistries. The shell layer of Monomix Core is modified with hydrophilic groups, which effectively enhances the hydrophilicity of the separation medium, and then minimizes the nonspecific binding (NSB) of biomolecules.
Key chromatographic features such as bead size, bead size uniformity, shell thickness and its uniformity, porous structure, functional group density in both shell layer and core layer, etc. can be consistently controlled and optimized to meet separation and purification challenges of various biomolecules.
A systematic platform solution for new biologics in any stage from analytical characterization to production, and from small scale to full scale production.
High capture capacity using flow-through mode.
Excellent bead surface hydrophilicity, negligible nonspecific binding (NSB) to biomolecules, and excellent biocompatibility.
Robust mechanical stability, excellent tolerance to high pressure and high flow rate.
Can withstand higher flow rates when compared with traditional agarose-based multimodal chromatographic media.
High resolution, high column efficiency, and high recovery.
Excellent batch to batch repeatability & reproducibility.
Minor bed volume change under common column packing conditions.
Customization with new features, such as mild CIP condition, etc. is available upon request.