Sepax Technologies, Inc. develops and manufactures products in the area of chemical and biological separations, biosurfaces and proteomics. Sepax product portfolio includes 1) liquid chromatography columns and media, 2) bulk resin for preparative and process chromatography, and 3) natural product and Chinese traditional medicine separation and purification.
LC Column Technology
As a manufacturer of the most comprehensive and highest quality LC columns, Sepax has developed wide range of patented and proprietary technologies in the areas of resin synthesis and surface chemistry that has established itself as the leader in chromatographic separation with the applications from small pharmaceutical molecules to biological macromolecules to virus separation to nanomaterials.
In the biological separation area, we manufacture the most comprehensive and highest performance LC phases and bulk resins, including ProteomixTM ion-exchangers (SAX, WAX, SCX and WCX) with standard particle size selection: 1.7, 3, 5 and 10 µm, NanofilmTM, SRTTM and CNTTM size exclusion chromatography, CarbomixTM Ca-NP series of phases for carbohydrate separation, and sub-2 micron particles and columns.
For your routine separations, Sepax produces the GP, HP and Bio line of reversed phases, normal phases and HILIC columns that equal or surpass the performance of many popular phases. However, we offer cost savings to your lab.
Sepax has complete product lines for Supercritical Fluid Chromatography (SFC) separation, including the phases of Silica, Diol, Amino, Pyridine, SCX, and Cyano from analytical to preparative scale.
Coating Technology for Capillary Electrophoresis
Sepax Technologies has developed a proprietary surface coating technology, which initiates polymerization reaction right and only on the surface, thus allows to coat the thinnest available capillary column (down to 5µm in I.D.) from the market place. Our unique process allows us to coat a 5 nm thick polymer film on internal surface of a capillary column uniformly, with selective neutral, cationic or anionic polymer layer. These coated capillary columns with controlled or reversed EOF provides a very reliable and highly efficient separation (N >1.5×10
6/m for 20µm ID column) for Capillary Electrophoresis (CE), which has widely application in high-throughput analysis, such as proteomics.
Preparative Columns and Bulk Media for Process Chromatography
For the preparative separation, Sepax offers bulk resins and preparative columns with the column ID of 10, 21.2, 30, and 50 mm and the length from 50 to 300 mm. Sepax's bulk resins cover both silica and polymer based media with the particle size selection from 1 to 100 microns. Silica based materials cover silica bonded with C18, C8, C4, C2, Diol, Cyano, Amino, Pyridine, SAX, WAX, and custom synthesis. Polymer media cover porous and non-porous PS/DVB, polymethacrylate and ion-exchange particles. The uniqueness of those bulk packings includes narrow-dispersed size distribution, excellent resistance to high pressure, high capacity and high separation efficiency. Their pore size selection is well controlled at 100, 300, 500, 1000 and 2000 Å.
Surface Technology
Sepax Technologies is a leader in surface Chemistry. Our proprietary and patented technologies can be a great asset for your research and application needs. Sepax Technologies has developed a number of unique chemical processes for synthesizing polymeric thin film on both flat and particle surfaces. Our unique process allows to coat selective neutral, cationic or anionic polymer layers with a controlled thickness from 1 to 50 nm on internal or open surface uniformly. We are open to proposal for joint project in this area to benefit all of us. If you have any such needs, please contact us.
Separation and Purification of Natural Products and Traditional Chinese Medicine
A typical natural plant has more than 300 different species or compounds. Those mixtures are composed of a variety of species from small molecules to natural polymers, such as polysaccharides. It is costly and time consuming to get each of those species isolated and purified. Sepax Technologies has developed a series of practical and cost-effective separation processes to purify a large number of compounds from the extracts of natural products and traditional Chinese medicine plants. Each production line isolates and purifies more than 2,000 compounds which are well characterized by LC/MS.
Our technologies are focused on three areas:
(1) Provide service for purification of natural products and biological samples,
(2) Offer high purity compounds from natural plants as the reagents or standard chemicals, and
(3) Accumulated the active compound library to screen for drug candidates.
Separation and Purification Capabilities
- Extraction
- Flash Chromatography
- Thin layer chromatography
- Analytical HPLC separation
- Preparative LC separation
- Lyophilization
Characterization & Identification Capabilities
- LC chromatography
- UV-vis
- LC/MS
- NMR
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