Using porous polyacrylate particle as the support, Generik MC-SP, CM, QAE and DEAE ion-exchange media are synthesized. Generik MC-SP is a strong cation exchanger with sulfonate functional group. Generik MC-CM is a weak cation exchanger with carboxylate functional group. Generik MC-QAE is a strong anion exchanger with quaternary ammonium functional group. Generik MC-DEAE is a weak anion exchanger with tertiary amine functional group. The controlled manufacturing process guarantees high batch-to-batch reproducibility. Their high capacity and high mechanical strength enable those media ideal for preparative separation and purification of proteins, peptides, nucleic acids, antibodies, and other biopharmaceuticals.

Typical Properties

These properties are typical but do not constitute specifications.

Products		Generik MC-Q	Generik MC-SP	Generik MC-DEAE	Generik MC-CM
Ion-exchanger type		Strong anion	Strong cation	Weak anion	Weak cation
Functional group		-N+(CH3)3	-SO3-	-HN+ (C2H5)2	-CH2COO-
Ionic capacity (meq/mL)		0.32-0.37	0.18-0.22	0.15-0.21	0.14-0.19
Average particle size (µm)		30, 60	30, 60	30, 60	30, 60
Average pore size (Å)		800	800	800	800
Storage solvent		20% ethanol	20% ethanol	20% ethanol	20% ethanol
DBC*		45 mg/mL	42 mg/mL	32 mg/mL	33 mg/mL
Chemical stability		Commonly used aqueous buffers, such as phosphate, Tris, acetate.
Cleaning solutions		0.5 M HCl, 0.5 M NaOH
pH stability		2~13	2~13	2~13	2~13
Volume change	pH 2-13	<1%	<1%	<1%	<1%
	0.01-1.0M NaCl	<1%	<1%	<1%	<1%
Regeneration salt		1-2 M NaCl	1-2 M NaCl	1-2 M NaCl	1-2 M NaCl

*DBC (Dynamic Binding Capacity) measurement method: for Generik MC-Q and Generik MC-DEAE, 10.0 mg/mL of BSA in 50 mM Tris buffer, pH 8.7, column size 10×150 mm, linear flow rate 212 cm/h, 10% breakthrough. For Generik MC-SP and Generik MC-CM, 10.0 mg/mL of lysozyme in 50 mM phosphate buffer, pH 6.0, column size 10×150 mm, linear flow rate 230 cm/h, 10% breakthrough.

• High chemical stability for low leaching
• Spherical particles with narrow particle size distribution
• High accessible surface area and high loading capacity
• High retentativity and selectivity
• Wide pH applications (pH=2-13)
• High lot to lot consistency
• Available from grams to multi-Kilogram

• Purification of proteins, peptides, proteins, nucleic acids, oligonucleotides and antibodies
• Suitable for heparin purification
• Solid phase extraction
• Flash chromatography
• Process purification

Phase	Particle Size	Pore Size	P/N	Package Available*
Generik MC30-SP	30 µm	800 Å	273030-0000	0.5, 1, 5, 10, 25 L
Generik MC30-CM	30 µm	800 Å	274030-0000	0.5, 1, 5, 10, 25 L
Generik MC30-Q	30 µm	800 Å	275030-0000	0.5, 1, 5, 10, 25 L
Generik MC30-DEAE	30 µm	800 Å	276030-0000	0.5, 1, 5, 10, 25 L
Generik MC60-SP	60 µm	800 Å	273060-0000	0.5, 1, 5, 10, 25 L
Generik MC60-CM	60 µm	800 Å	274060-0000	0.5, 1, 5, 10, 25 L
Generik MC60-Q	60 µm	800 Å	275060-0000	0.5, 1, 5, 10, 25 L
Generik MC60-DEAE	60 µm	800 Å	276060-0000	0.5, 1, 5, 10, 25 L

*The resins are stored and shipped in 20% ethanol in water. Dry resin is available upon request.