GP-C18 uses full coverage bonded silica packing, which provides exceptionally high stability. The unique mono-functional bonding chemistry of GP-C18 avoids the formation of multiple C18 layers. Such uniform stationary phase allows the separation to achieve high selectivity and high efficiency.
Silica:
Spherical, high purity (<10 ppm metals)
Pore size:
120Å
Particle size:
1.8, 3, 4, 5, 7, and 10 µm
Pore volume:
1.0 ml/g
Surface area:
300 m²/g
Phase structure:
Monomeric and fully endcapped
% Carbon:
17%
Highly controlled chemistry of monolayer formation and end-capping
Extremely high column-to-column reproducibility
High selectivity and efficiency for separations
Suitable for separations of acidic, neutral and basic organic compounds, as well as pharmaceuticals, peptides, and others
Recommended for separations in organic or mixed organic/aqueous mobile phases.
Stability
SepaxGP-C18 uses full coverage bonded silica packing, which provides exceptionally high stability. Figure below shows the highly reproducible retention time for three standard compounds: aniline, anisole and toluene after 13,000 column volume runs in a mobile phase of 85% methanol and 15% water. Such high stability allows SepaxGP-C18 extremely suitable for validation of various analytes.
Selectivity for GP-C18 and the Competitors' C18 Phases
Selectivity is very important for detection of the components of low abundance and impurities from the analysis of pharmaceuticals in the real applications. The comparative tests shown below from the method development of a drug molecule clearly demonstrated that GP-C18 is among the best products for high selectivity and sensitivity in detecting low abundant components and the impurities.
[1] Guard column [2] One-piece PEEK coupler, recommended to connect columns in series. [3] PEEK/Stainless Steel coupler, recommended to connect columns of IDs > 7.8 mm in series. [4] Column coupler with 10cm length flexible tubing,10-32 fitting with 1/16 OD PEEK tubing. Recommended to connect analytical columns in series [5] For 21.2x10mm guard cartridge
[1] Guard column [2] Guard Cartridge only. [3] Guard Cartridge with holder. [4] One-piece PEEK coupler, recommended to connect columns in series. [5] PEEK/Stainless Steel coupler, recommended to connect columns of IDs > 7.8 mm in series. [6] Column coupler with 10cm length flexible tubing,10-32 fitting with 1/16 OD PEEK tubing. Recommended to connect analytical columns in series [7] For 21.2x10mm guard cartridge
[1] Guard Cartridge with holder. [2] Guard column [3] Guard Cartridge only. [4] One-piece PEEK coupler, recommended to connect columns in series. [5] PEEK/Stainless Steel coupler, recommended to connect columns of IDs > 7.8 mm in series. [6] Column coupler with 10cm length flexible tubing,10-32 fitting with 1/16 OD PEEK tubing. Recommended to connect analytical columns in series [7] For 21.2x10mm guard cartridge
[1] Guard column [2] One-piece PEEK coupler, recommended to connect columns in series. [3] PEEK/Stainless Steel coupler, recommended to connect columns of IDs > 7.8 mm in series. [4] Column coupler with 10cm length flexible tubing,10-32 fitting with 1/16 OD PEEK tubing. Recommended to connect analytical columns in series [5] For 21.2x10mm guard cartridge
